Type of Spiritual Experience
According to Wikipedia "Untreated PKU can lead to intellectual disability, seizures, and other serious medical problems. The best proven treatment for classical PKU patients is a strict phenylalanine-restricted diet supplemented by a medical formula containing amino acids and other nutrients. In the United States, the current recommendation is that the PKU diet should be maintained for life"
A description of the experience
Tetrahydrobiopterin (BH4, THB, trade name Kuvan) or sapropterin (INN) is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases Chemically, its structure is that of a reduced pteridine derivative.
Tetrahydrobiopterin, under the brand name Kuvan was approved by the United States (U.S.) Food and Drug Administration (FDA) on December 13, 2007 and European Medicines Agency (EMA) in 2008, as a synthetic preparation of the dihydrochloride salt of the substance containing ascorbic acid, used in the treatment of PKU and tetrahydrobiopterin deficiencies.
A deficit in tetrahydrobiopterin biosynthesis and/or regeneration can result in phenylketonuria (PKU) from excess L-phenylalanine concentrations Phenylketonuria (PKU) (phenyl + ketone + -uria; /ˌfinəlˌkitɵnˈjʊəriə/) is an inborn error of metabolism involving impaired metabolism of the amino acid phenylalanine. Phenylketonuria is caused by absent or virtually absent phenylalanine hydroxylase (PAH) enzyme activity. The condition is also known as "phenylalanine hydroxylase deficiency."
On Jan, 06, 2017 1,633 people reported to have side effects when taking Kuvan.
Among them, 2 people (0.12%) have Hallucination
On Jan, 2, 2016: 597 people reported to have side effects when taking Kuvan. Among them, 5 people (0.84%) have Death.