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Is Postpartum Depression a Disease of Modern Civilization?

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027731

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A description of the experience

Curr Dir Psychol Sci. Author manuscript; available in PMC 2017 May 11.
 
Published in final edited form as:
Curr Dir Psychol Sci. 2014 Dec; 23(6): 395–400.
Published online 2014 Dec 16. doi:  [10.1177/0963721414547736]
PMCID: PMC5426853
NIHMSID: NIHMS728472
PMID: 28503034
Is Postpartum Depression a Disease of Modern Civilization?
Jennifer Hahn-Holbrook1 and Martie Haselton2,3,4
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The publisher's final edited version of this article is available at Curr Dir Psychol Sci
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Abstract
Access to calorie-dense foods, medicine, and other comforts has made modern humans healthier than our prehistoric ancestors in many respects. However, the epidemics of obesity, diabetes, and cardiovascular disease suggest that there are also drawbacks to modern living. Here, we address the question of whether the dramatic cultural changes that have occurred over the past century have inflated rates of postpartum depression, adding postpartum depression to the list of “diseases of modern civilization.” We review evidence from cross-cultural, epidemiological, and experimental studies documenting associations between postpartum depression and modern patterns of early weaning, diets deficient in essential fatty acids, low levels of physical activity, low levels of sun exposure, and isolation from kin support networks, all of which mark significant divergences from lifestyles believed to have been typical throughout human evolutionary history. This “mismatch hypothesis” of postpartum depression integrates research across diverse research areas and generates novel predictions.
Keywords: postpartum depression, evolutionary medicine, omega-3 fatty acids, social support, exercise

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Common maladies such as cardiovascular disease, diabetes, and even tooth cavities are rare in societies characterized by lifestyles resembling those of the human ancestral past (Gluckman & Hanson, 2006). These “diseases of modern civilization” are thought to largely result from mismatches between the modern world and the ancient environments to which humans are adapted. Here, we propose that such a mismatch might also account for an increased prevalence of postpartum depression today.

Approximately 13% of women worldwide will experience depressive symptoms within the first 3 months postpartum (O'Hara & Swain, 1996). Postpartum depressive symptoms result in harmful disruptions in parenting behaviors (Paulson, Dauber, & Leiferman, 2006), which are associated with marital problems and cognitive, social, and health deficits in children (Burke, 2003). These symptoms might even lead to an increased risk of infant death (Mitchell et al., 1992). Given these dramatic costs, the simple existence of postpartum depression is an evolutionary puzzle—why does it exist at all? As we detail below, there is convergent evidence from cross-cultural, epidemiological, and experimental studies documenting associations between postpartum depression and early weaning, diets deficient in essential fatty acids, low levels of physical activity, and isolation from kin support networks, all of which are typical of modern parenting practices but were probably rare in the human evolutionary past.

In framing this mismatch hypothesis of postpartum depression, we draw on previous evolutionary-mismatch frameworks for understanding diseases of modern civilization (see Gluckman & Hanson, 2006; Nesse & Williams, 1996), in addition to the Pathogen Host Defense model (Raison & Miller, 2013), which conceptualizes depressive symptoms as a biologically functional suite of sicknesslike behaviors employed to decrease activity and increase vigilance when the body's immune system is activated in response to disease or stress (Dantzer, O'Conner, Freund, Johnson, & Kelley, 2008). Inflammation leads to signaling in the brain that can trigger the development of depressive symptoms and other sickness-like behaviors (Dantzer et al., 2008). Although there are many likely mechanisms underlying relationships between the diverse risk factors we present here and postpartum depression, a striking theme is that most have been linked to inflammatory processes during pregnancy or postpartum.

Dietary Mismatches

Although hunter-gather diets varied significantly by geography, culture, and season, scientists have pieced together a picture of the preagricultural ancestral diet from chemical analysis of human skeletal remains and archaeological excavations. From this evidence, it appears that the preagricultural human diet comprised wild meats (approximately 30% of calories), starchy tubers (approximately 30% of calories), and seasonal fresh fruits and vegetables (approximately 30% of calories; see Eaton, 2006, for a review). Ancestral diets tended to be richer in essential micronutrients, fiber, and fatty acids than modern Western diets (Eaton, 2006), although they were likely not necessarily better in all respects, given that periods of food shortage and caloric restriction were probably relatively common. The agricultural revolution 10,000 years ago afforded humans the potential to grow and store large quantities of energetically rich grains. Modern diets replace much of the micronutrient-dense, perishable foods with grains (Eaton, 2006). This pattern has led researchers to conclude that many modern populations are overfed yet undernourished (Gluckman & Hanson, 2006).

For example, Western diets are relatively low in omega-3 essential fatty acids (Eaton, 2006). These “good fats” make up approximately 20% of the human brain by volume, have potent anti-inflammatory effects (Simopoulos, 1991), and are prevalent in wild-caught organ meats, which were regularly consumed by preagricultural humans (Eaton, 2006). The primary protein source in Westernized countries, by contrast, is muscle meat derived from grain-fed livestock, which has lower levels of fat and much lower levels of omega-3 fatty acids (Eaton, 2006). Further, staple fat sources in the Western diet (e.g., dairy and vegetable oils), while rich in essential unsaturated omega-6 fatty acids, contain little omega-3 fatty acids. This good-fat deficit is further exacerbated by pregnancy and lactation because already-scarce maternal stores are tapped to supply the developing infant (De Vriese, Christophe, Maes, 2003). Supporting a possible link between omega-3s and postpartum depression, a recent meta-analysis aggregating results of 29 earlier randomized controlled trials showed that omega-3 fatty acid supplementation was effective as a treatment for depression (Appleton, Rogers, & Ness, 2010).

Seafood is high in omega-3 fatty acids, and rates of postpartum depression cross-culturally are negatively related to pounds of seafood consumed per person per year (see Fig. 1). In addition, large epidemiological studies have documented negative associations between levels of circulating omega-3 fatty acids in pregnancy and risk for postpartum depression (see Markhus et al., 2013, for a review, but see Makrides et al., 2010, for a report of a small, nonsignificant reduction in postpartum depression in a randomized controlled trial of omega-3 supplementation).

Cross-national rates of postpartum depression as a function of seafood consumption. The graph shows the inverse correlation between apparent seafood consumption (in pounds per person, per year; calculated by adding the country's yearly seafood catch and imports minus its exports) and prevalence of postpartum depression by country. This association remained significant after adjusting for gross domestic product and after removing outlying Asian nations. EPDS = Edinburgh Postpartum Depression Scale. Reprinted from “Seafood Consumption, the DHA Content of Mothers' Milk and Prevalence Rates of Postpartum Depression: A Cross-National, Ecological Analysis,” by J. R. Hibbeln, 2002, Journal of Affective Disorders, 69, p. 22 Copyright 2002 by Elsevier. Reprinted with permission.
Additional research is needed to address other dietary discontinuities that might impact rates of postpartum depression, including carbohydrate- and sugar-rich diets and overfeeding, which have been linked to chronic inflammation and depression outside of the context of pregnancy (Capuron et al., 2008).

Breast-Feeding Mismatches

Breast-feeding is an ancient mammalian adaptation that dramatically changes maternal hormone profiles in ways that are likely to facilitate mothers' postpartum adjustment. However, breast-feeding rates are much lower today than they were for the vast majority of human history. Stable nitrogen (δ15N) and carbon (δ13C) isotopes unique to breast milk, which have been detected in prehistoric fossils, suggest that prehistoric infants were primarily fed breast milk for the first 1.5 years of life and were weaned sometime between 2 and 4 years of age, on average (Clayton, Sealy, & Pfeiffer, 2006). A review of 64 small-scale societies placed weaning between the ages of 2 and 4 years, providing converging evidence of the duration of species-typical lactation for humans (Dettwyler, 1995). By contrast, in 2011, only 49% of infants in the United States were breast-fed until 6 months of age, and approximately 20% of mothers never initiate breast-feeding at all (United States Centers for Chronic Disease Control and Prevention, 2014). Could this dramatic change in breast-feeding influence rates of postpartum depression?

Surprisingly little research has directly addressed this question, but several effects of breast-feeding provide plausible pathways through which breast-feeding could have protective effects. For example, breast-feeding releases the hormones oxytocin and prolactin, each of which have anxiolytic effects and are negatively associated with postpartum depressive symptomatology (Skrundz, Bolten, Nast, Hellhammer, & Meinlschmidt, 2011; Zonana & Gorman, 2005). Experimental studies in rats and correlational studies in humans have found that, compared with nonlactating mothers, lactating mothers show a reduced inflammatory reaction to stress (Groer & Davis, 2006; Jaedicke, Fuhrmann, & Stefanski, 2009). Further, breast-feeding is associated with a reduced incidence of health problems in infants and mothers over the long term, potentially leading to positive downstream consequences for maternal mental health (Hahn-Holbrook, Glynn, et al., 2013).

Consistent with these hints, in the only true experiment on breast-feeding and mood in humans, women using both breast-feeding and formula-feeding methods reported lower levels of negative affect when randomly assigned to breast-feed versus formula feed their baby in the lab (Mezzacappa & Katlin, 2002). Further, 12 cross-sectional studies have found lower incidences of depressive symptomatology among women who breast-fed compared with woman who exclusively formula fed (see Dennis & McQueen, 2009, for a review). From the correlational data, one cannot conclude that that breastfeeding offers mental health benefits; an alternative hypothesis seems equally plausible—that women who are depressed are simply less likely to breast-feed (Dennis & McQueen, 2009). Recently, however, two longitudinal studies examined whether breast-feeding preceded and predicted a reduced risk of depression. These studies showed that breast-feeding fewer times per day at 3 months (Hahn-Holbrook, Glynn, et al., 2013) and weaning before 6 months (Ystrom, 2012) predicted higher risk of later postpartum depression, in line with the possibility that breast-feeding might have a protective effect (but see Dennis & McQueen, 2007). Given the evidence, we hypothesize that modern rates of postpartum depression could partly be a consequence of mothers confronting the challenges of new motherhood without the stress-regulation benefits of breast-feeding (also see Gallup, Pipitone, Carrone, & Leadholm, 2010, for an alternative evolutionary perspective on links between breast-feeding and postpartum depression).

Exercise Mismatches

There is little doubt that modern humans, particularly in the West, get less exercise than did ancestral humans. The introduction of mechanized farming technologies, for example, reduced the total basal metabolic demands of farm workers by 50% in Japan and 65% in Britain (Eaton, Eaton, & Konnor, 1997). Moreover, contemporary hunter-gathers burn an estimated 3,000 calories a day, as compared with 2,000 calories a day for U.S. adults (Eaton et al., 1997).

Exercise acts on multiple pathways thought to influence depression, including chronic inflammation, insulin resistance, and serotonergic and dopaminergic activity (Lucassen et al., 2010). Moreover, these biological systems undergo dramatic changes during pregnancy and lactation (Elenkov et al., 2001), which raises the possibility that exercise-induced regulation of these systems might be even more important during the postpartum transition. Consistent with this view, a meta-analysis of five randomized controlled trials showed that exercise interventions reduced rates of postpartum depression, compared with non-active treatment or social support (Daley, Jolly, & MacArthur, 2009). This result echoed results from a larger meta-analysis of 11 studies documenting decreases in general clinical depression after exercise interventions (Stathopoulou, Powers, Berry, Smits, & Otto, 2006).

Sun-Exposure Mismatches

The primary source of vitamin D synthesis in humans is sun exposure, yet modern humans are increasingly sheltered from the sun. This discontinuity has led to an epidemic of vitamin D deficiency (Dawodu & Wagner, 2007).

  • Eighteen percent of pregnant woman in the United Kingdom,
  • 25% in the United Arab Emirates,
  • 42% in northern India,
  • 61% in New Zealand,
  • 45% of African American women in the United States, and
  • 60% to 84% of non-Western women in the Netherlands

are deficient in circulating levels of vitamin D (Dawodu & Wagner, 2007). Shortfalls in vitamin D are exacerbated by the nutritional demands of pregnancy and lactation, which has led to outbreaks of rickets among some breast-fed U.S. infants (Arora & Hobel, 2010).

Vitamin D acts on the immune system by stimulating antimicrobial responses that suppress inflammation (Arora & Hobel, 2010). Hence, vitamin D deficiency during pregnancy increases mothers' susceptibility to infections and inflammation (Arora & Hobel, 2010), potentially leading to postpartum depression. Consistent with this notion, a cross-sectional study of 176 pregnant African American women found that vitamin D deficiency was associated with depressive symptoms (Cassidy-Bushrow, Peters, Johnson, Li, & Rao, 2012). Although no vitamin D intervention studies of depression in pregnancy or postpartum have yet been conducted, a double-blind randomized controlled trial in overweight adults showed that vitamin D supplementation significantly reduced depressive symptoms, and a meta-analysis of correlational studies documented a similar association (Anglin, Samaan, Walter, & McDonald, 2013).

Child Care Mismatches

Hunter-gather families typically live in kin groups in which grandparents, aunts and uncles, and older siblings assist mothers and fathers with their young children (Burkart, Hrdy, & Van Schaik, 2009). In contrast, in the Western world, nuclear families often live hundreds or thousands of miles away from close kin. Further, Western families have fewer children spaced closer together in age, simultaneously making it less likely that older siblings will be available to help with child care and more likely that mothers will need to simultaneously care for multiple very young children. A meta-analysis documented that weak or absent social support was one of the most consistent predictors of postpartum depression (O'Hara & Swain, 1996). Therefore, it is plausible that the shift from multigenerational families to smaller nuclear families might impact women's ability to cope with the demands of motherhood.

The “Latina paradox” provides additional suggestive evidence. The paradox is that mothers who emigrate from Mexico to the United States have lower rates of postpartum depression than White mothers, even though immigrant mothers are relatively disadvantaged economically and are more often unmarried (Campos et al., 2008). The factor thought to explain this paradox is the high degree of family and community support experienced by Latina women, compared with richer but more isolated White women (Campos et al., 2008). Further, in a longitudinal study of 210 women from diverse economic and ethnic backgrounds, maternal support from family, but not the baby's father, buffered mothers against increases in the stress hormone placental corticotropin-releasing factor in pregnancy, reducing their risk for postpartum depression (Hahn-Holbrook, Dunkel Schetter, Chander, & Hobel, 2013).

Nannies, babysitters, and daycare centers can help take the place of extended-family child care networks. However, these solutions are expensive and might not be able to replace the emotional support provided by family that is important for maternal coping postpartum.

Other Risk Factors

The evidence for the mismatch hypothesis is compelling and could help explain the relatively high rates of postpartum depression in many modern populations. However, there are additional predictors of postpartum depression that might not be more common today than they were in the ancestral past, including chronic life stress, father abandonment, infant health problems, and history of depression. These factors are likely to have other etiological relationships with postpartum depression and different evolutionary foundations than the associations we have described (see Hagen, 1999, for an evolutionary perspective on postpartum depression that incorporates these risk factors). In sum, the mismatch hypothesis of postpartum depression is an important—if incomplete—account for cases of postpartum depression.

Conclusion

The mismatch hypothesis of postpartum depression can serve as a guide for future research. For example, one prediction stemming from this hypothesis is that rates of postpartum depression will vary across cultures because of differences in breast-feeding, traditional diets, active lifestyles, daily sun exposure, and the presence of kin.

Further, although there is substantial evidence of associations between a variety of modern factors and increased risk for postpartum depression, more research is needed to establish causal relationships and to develop and test potential interventions. Some interventions suggested here, such as vitamin D and omega-3 fatty acid supplementation, are promising because of their simplicity. This framework also suggests that some advice given to pregnant women—for example, to avoid sun exposure (to prevent skin cancer) and limit fish consumption (because of mercury exposure)—might put them at risk of postpartum depression. Other interventions, such as increasing breast-feeding and exercise, might be more challenging to implement because of multiple, competing demands on women today. Our hope is that the mismatch-hypothesis framework will trigger additional research and identify interventions that will enhance outcomes for mothers and their children.

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