Observations placeholder
Histidine, histamine and migraine
Identifier
019133
Type of Spiritual Experience
Background
Histidine is converted to histamine
Histamine causes vasodilation [as part of the immune response]
Vasodilation can be one cause of the pain of migraines
BUT histidine is not the cause of migraines, all this means is that there is some pathogenic response, some immunological response at work here and migraine is being caused by a pathogen on the brain that is prompting the reaction.
A description of the experience
CNS Neurol Disord Drug Targets. 2015;14(3):345-9.
Changes in Serum Amino Acids in Migraine Patients without and with Aura and their Possible Usefulness in the Study of Migraine Pathogenesis.
Domitrz I1, Koter MD, Cholojczyk M, Domitrz W, Baranczyk-Kuzma A, Kaminska A.
- 1Department of Neurology, Medical University, 1a Banacha Street, 02-097 Warsaw, Poland. izabela.domitrz@wum.edu.pl.
Abstract
BACKGROUND:
Results of several studies suggest that serum amino acids monitoring in migraine might be useful as an objective measurement of the disease status.
OBJECTIVE:
The aim of the present work was to analyze the profile of aliphatic and aromatic amino acids in blood serum of migraine patients without and with aura between attacks.
METHODS:
A total number of 37 migraine patients (26 with migraine without aura and 11 with migraine with aura), mean age 39±12 years, and 40 age-matched healthy subjects as the control group, mean age 38±14 years, were included into the study. The levels of glutamic acid, glutamine, histidine (His), valine (Val), isoleucine, leucine (Leu), phenyloalanine, lysine were evaluated.
RESULTS:
The level of His was significantly higher in both groups of migraine patients (without and with aura) compared to the control group (F(2,74)=10.17, p=0.00). The levels of Val and Leu were significantly different in migraine without but not with aura, when compared with the control group (F(2,74)=4.70, p=0.01 and F(2,74)=4.39, p=0.02, respectively).
CONCLUSION:
We found higher level of His in migraine patients without and with aura and lower level of Val and Leu in patients with migraine without aura.
PMID:
25714963