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Fish oil, Linseed oil and arthritis

Identifier

005663

Type of Spiritual Experience

Background

A description of the experience

Phytother Res. 2012 Feb;26(2):246-52. doi: 10.1002/ptr.3535. Epub 2011 Jun 8. Linseed oil: an investigation of its antiarthritic activity in experimental models. Singh S, Nair V, Gupta YK.  Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. surenderaiims@gmail.com

Food sources rich in omega-3 fatty acids have been valued for their beneficial effect in the management of inflammatory disorders. The present study evaluates the antiarthritic and immunomodulatory activity of Linum usitatissimum fixed oil (LUFO) in experimental models.

The LUFO produced a dose-dependent reduction in joint swelling and circulating TNF-α levels in both preventive and curative protocols of arthritis induced by complete Freund's adjuvant (CFA). Expression of TNF-R1 and Interleukin (IL) 6 proteins in the arthritic paw was also significantly reduced in the LUFO-treated animals. In the cotton pellet induced granuloma model, LUFO treatment significantly reduced the dry granuloma weight as compared with the control group.

Results of our present study thus demonstrate the antiarthritic and disease modifying activity of LUFO. We believe that dietary incorporation of LUFO may be beneficial in the prevention and management of rheumatoid arthritis and other chronic inflammatory disorders.

Copyright © 2011 John Wiley & Sons, Ltd.

PMID: 21656600

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Rheumatoid arthritis

Suppressions

ALA
Cod liver oil
Eggs
Fish
Flax

Commonsteps

References