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Observations placeholder

Fareston, Toremifene

Identifier

027437

Type of Spiritual Experience

None

Background

A description of the experience

 

Toremifene, trade name Fareston, is a chlorinated tamoxifen derivative, which allegedly causes fewer DNA adducts in liver than seen with tamoxifen in preclinical studies and was developed to avoid hepatic carcinomas. It is used as endocrine therapy in women with ER/PR-positive stage 4 or recurrent metastatic breast cancer and has demonstrated similar efficacy compared to tamoxifen as adjuvant treatment of breast cancer and in the treatment of metastatic breast cancer.[6]

Fareston and Death - from FDA reports

Death is found among people who take Fareston, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Oxycontin, and have Breast cancer. This review analyzes which people have Death with Fareston. It is created by eHealthMe based on reports of 636 people who have side effects when taking Fareston from FDA, and is updated regularly.
636 people reported to have side effects when taking Fareston.
Among them, 19 people (2.99%) have Death

Time on Fareston when people have Death *:
< 1 month: 20 %
1 - 6 months: 40 %
6 - 12 months: 20 %
1 - 2 years: 0.0 %
2 - 5 years: 20 %
5 - 10 years: 0.0 %
10+ years: 0.0 %

Gender of people who have Death when taking Fareston *:
female: 94.74 %
male: 5.26 %

Top conditions involved for these people *:
Breast Cancer: 18 people, 94.74%
Hormone Replacement Therapy: 14 people, 73.68%
Breakthrough Pain: 14 people, 73.68%
Metastases To Bone (cancer spreads to bone): 1 person, 5.26%
Cancer Pain: 1 person, 5.26%

 

Most common side effects over time *:

< 1 month:
White blood cell count decreased
Acute hepatic failure
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Lip swelling
Rectal stenosis (narrowing of rectum)
Vomiting
Blood urea increased
Cholangitis (infection of the bile duct)
Coma hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma)
Death
1 - 6 months:
Hepatic function abnormal
Interstitial lung disease
Liver disorder (liver diseases)
Pyrexia (fever)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
White blood cell count decreased
Anaemia (lack of blood)
Bone disorder
Breast cancer female
Hypertriglyceridaemia (excess of triglycerides in the blood)
6 - 12 months:
Osteonecrosis of jaw (death of bone of jaw)
White blood cell count decreased
Delirium (wild excitement)
Interstitial lung disease
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Tooth extraction
Blood creatinine increased
Bone disorder
Exposed bone in jaw
Hepatic function abnormal
1 - 2 years:
Uterine polyp (a mass in the inner lining of the uterus)
Genital haemorrhage (bleeding from genital)
Pain
Productive cough
Respiratory disorder (respiratory disease)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hyperplasia (enlargement of an organ or tissue)
2 - 5 years:
Cardiac arrest
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Endometrial cancer
Endometrial hypertrophy (enlargement of uterine wall from the increase in size of its cells)
Endometrial stromal sarcoma (endometrial tumour arising from the stroma (connective tissue))
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ovarian cancer (cancer of ovary)
Sarcoma uterus (type of tumour of uterus cancer)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Uterine fibroids (benign growths of the muscle inside the uterus)
5 - 10 years:
Arthralgia (joint pain)
Fall
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Restless legs syndrome (a powerful urge to move your legs)
Varices oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach)
10+ years:
Pelvic neoplasm (tumours or cancer of the pelvic region)
Pulmonary artery thrombosis (blockage of the main artery of the lung)
not specified:
Abdominal pain
Interstitial lung disease
Thrombocytopenia (decrease of platelets in blood)
Liver function tests nos abnormal
Osteonecrosis of jaw (death of bone of jaw)
Pyrexia (fever)
Vaginal discharge
White blood cell count decreased
White blood cell count increased
Abdominal discomfort


Most common side effects by gender *:

female:
White blood cell count decreased
Interstitial lung disease
Osteonecrosis of jaw (death of bone of jaw)
Hepatic function abnormal
Abdominal pain
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Tooth extraction
White blood cell count increased
Liver function tests nos abnormal
male:
Pancreatitis (inflammation of pancreas)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Interstitial lung disease
Lymphocyte percentage increased
Lymphocyte stimulation test positive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Respiratory disorder (respiratory disease)
Vomiting

The source of the experience

eHealthme

Concepts, symbols and science items

Concepts

Symbols

Science Items

SERMs

Activities and commonsteps

Activities

Overloads

Breast cancer
Chemotherapy drugs

Commonsteps

References