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Dr Duke’s list of Chemicals and their Biological Activities in: Sanguinaria canadensis L. (Papaveraceae) -- Bloodroot



Type of Spiritual Experience


A description of the experience

Dr Duke’s list of Chemicals and their Biological Activities in: Sanguinaria canadensis L. (Papaveraceae) -- Bloodroot


ALKALOIDS Root 18,000 - 70,000 ppm DUKE1992A

No activity reported.


Aldose-Reductase-Inhibitor IC50=27.9 uM rat SPJ4:45 ; Analgesic DUKE1992B ; Antiarrhythmic GMJ ; Antifibrillary GMJ ; Soporific PJB1(1)


Antiarrhythmic DUKE1992B ; Cardioactive DUKE1992B ; Oxytocic JBH


(+)-Inotropic MAB ; Abortifacient DUKE1992B ; Adrenolytic MAB ; Amebicide 200 ug/ml PAM EC83=100 ug/ml orl rat MAB ; Analgesic LRN-JUL91 ; Anesthetic LRN-JUL91 ; Antiacetylcholinesterase; Antiacne MAB ; Antiadrenergic KCH ; Antiaggregant; Antialzheimeran COX ; Antiamnesic MAB ; Antiangiogenic X15322253 ; Antiarrhythmic; Antiarthritic COX ; Antibacillus MIC=200 ug/ml PR14:303 ; Antibacterial 100 mg/4x/day LRN-JUL91 12.5-2,500 ug/ml PAM MIC=6-630 ug/ml PR14:303 ; Antibiotic PAM ; Anticancer; Anticariogenic MAB ; Antichlamydial PH2 ; Anticholecystitic 5-20 mg/3x/day/orl PAM ; Anticholera 150 mg/man/day MAR ; Anticirrhotic PAM ; Anticonjunctivitic 0.2% PAM ; Anticonvulsant 411 ; Antidiarrheic 100 mg/4x/day LRN-JUL91 ; Antidysenteric; Antiedemic MAB ; Antiendotoxic CAN ; Antienterotoxic PAM ; Antiesherichic; Antigiardial 10 mg/kg/day 414 ; Antiglaucomic AHP136 ; Antigonorrhea PJB1(3):231 ; Antihepatomic MAB ; Antihepatotic PMP25:62 ; Antiherpetic FEL ; Antihistaminic CAN ; Antiinflammatory; Antiischemic MAB ; Antileishmanic 10 ug/ml PR4(4):132 ; Antilipogenic IC63=10 uM MAB ; Antimalarial 0.14-0.36 ug/ml JE32:161 50 uM PR4(4):132 ; Antimitotic MAB ; Antimuscarinic CAN ; Antimyalgic FEL ; Antimycotic MAB ; Antineoplastic LRN-JUN87 ; Antinephritic PMP25:62 ; Antiperistaltic BRU ; Antipharyngitic PAM ; Antiphotooxidative JAF48:1058 ; Antiplasmodial IC50=0.14-0.36 ug/ml; Antipneumonic PAM ; Antipyretic 3 x aspirin; Antisalmonella PJB1(3):231 ; Antisecretory; Antiseptic 25 ug/ml; Antishigellic 12.5 ug/ml PAM ; Antispasmodic JBH ; Antispermigenic JE32:173 ; Antistaphylococcic PJB1(3):231 ; Antistrep PAM ; Antisyphilitic FEL ; Antitrachomic 0.2%; Antitrypanosomic 411 ; Antitubercular MIC=25 ug/ml; Antitumor (brain) IC91=150 ug/ml W&M ; Antiulcer; Antivaginitic KCH ; Antiviral KCH ; Astringent DUKE1992B ; Bilirubinolytic PH2 ; Calcium-Antagonist MAB ; Candidicide 414 ; Cardiodepressant KCH ; Cardiotonic; Carminative CAN ; Cholagogue AEHD1:99 ; Cholekinetic; Choleretic 411 ; Collyrium DUKE1992B ; COX-2-Inhibitor 100 ug/ml; Cyclooxygenase-Inhibitor DUKE1992B ; Cytotoxic JBH ; Digestive AHP137 ; Diuretic AHP137 ; Emetic AEHD1:101 ; Fungicide 12.5-150 ug/ml PAM ; Glaucomagenic AHP136 ; Hemostat DUKE1992B ; Hypocholesterolemic JE27:243 ; Hypoglycemic; Hypotensive; Immunostimulant; Lachrymatory MAB ; Larvicide 9 ppm JCE10:115 ; Leucocytogenic PH2 ; Lipase-Inhibitor MED ; Lipoxygenase-Inhibitor IC50=118 uM PM60:421 ; Mutagenic; Mycobactericide MIC=25-50 ug/ml PR14:303 ; Mydriatic MAB ; Myocardiodepressant DUKE1992B ; Myorelaxant AHP137 ; Pesticide DUKE1992B ; Phototoxic 9 ppm JCE10:115 ; Plasmodicide IC50=0.14-0.36 ug/ml POP:117 ; Prostaglandin-Synthesis-Inhibitor 25 mg/kg ivn rbt CHP12:526 ; Protisticide IC50=0.14-0.36 ug/ml POP:117 ; Respiradepressant MAR ; RNA-Depressant DUKE1992B ; RT-Inhibitor EMP5:222 ; Sedative; Stomachic PJB1(1) ; Topoisomerase-II-Inhibitor 2.5 uM PM61:414 ; Trichomonicide M29 ; Trypanocide; Uterocontractant; Uterotonic 411 ; Vagostimulant man AHP136 ; Vasoconstrictor 414 ; Vasodilator 2 mg/kg cat AHP136 ; Vermifuge PJB1(1) ; Vibriofuge LRN-JUL91


Antivagal DUKE1992B


CNS-Paralytic DUKE1992B


12-Lipoxygenase-Inhibitor MAB ; 5-Lipoxygenase-Inhibitor MAB ; Analgesic JE38:1 ; Antiacetylcholinesterase FT63(1):67 ; Antiaggregant PMP25:62 ; Antibacterial 411 ; Antiinflammatory 10 mg/kg orl rat (=5 mg indomethacin) CAN FT63(1):67 ; Antimitotic WIC ; Antineoplastic LRN-JUL92 ; Antiseptic FT63(1):67 ; Antitumor LEL ; Antitussive 411 ; Antiviral 411 ; Candidicide CAN ; Cytotoxic PJB1(1):171 ; DNA-Intercalator 411 ; Fungicide 1-5 mg/ml DUKE1992B ; Gram(+)icide CAN ; Gram(-)icide CAN ; Hypertensive 3-5 mg/kg ivn JE38:1 ; Hypotensive JE38:1 ; Immunostimulant; Irritant WIC ; Lipase-Inhibitor MED ; Molluscicide POP:74 ; Nematicide 50-100 ug/ml NIG ; Occulotensive DUKE1992B ; Paralytic DUKE1992B ; Pesticide DUKE1992B ; Respirainhibitor DUKE1992B ; Tetanic DUKE1992B ; Topoisomerase-I-Inhibitor JOC58:5025


No activity reported.


Antibacterial POP:74 ; Molluscicide POP:74 ; Pesticide DUKE1992B


Antiinflammatory PJB1(1):172 ; Antitumor PJB1(1):172 ; Myocontractant DUKE1992B


No activity reported.


Antiatherosclerotic X11413687 ; Antibacterial PR14:303 ; Antifibromyalgic 300 mg 3x/day PIL ; Antioxidant Synergist M11 ; Antiseborrheic LRN-JUN89 ; Antiseptic M29 ; Antitubercular PR14:303 ; Antitumor EMP6:235 ; Bacteristat DUKE1992B ; Bruchiphobe 382 ; Hemopoietic DUKE1992B ; Laxative? LRN-SEP91 ; Mycobactericide PR14:303 ; Pesticide DUKE1992B ; Sialogogue M29


No activity reported.


No activity reported.


No activity reported.


Abortifacient 70 mg/kg JE32:173 ; Aldose-Reductase-Inhibitor 50 uM BPB17:458 IC50=38.5 uM rat SPJ4:45 ; Amphicholeretic WIC ; Analgesic DUKE1992B ; Antiaggregant 100-1,000 uM CPB38:2320 ; Antiarrhythmic BRU ; Antibacterial; Anticholinergic BRU ; Antiinflammatory 100 mg/kg DUKE1992B ; Antiseptic 1,000 ppm DUKE1992B ; Antispasmodic BRU ; Antispermigenic JE32:173 ; Antitussive 411 ; Calcium-Antagonist KEB ; Convulsant DUKE1992B ; Gram(+)icide PJB1(1):184 ; Hypertensive <1 g/kg DUKE1992B ; Hypotensive >1 mg/kg DUKE1992B ; Myorelaxant JBH ; Pesticide DUKE1992B ; Sedative JBH ; Spasmogenic HH3 ; Uterotonic


No activity reported.

RESIN Plant: DUKE1992A

No activity reported.


No activity reported.


Antitumor DUKE1992B


No activity reported.

SANGUINARINE Root 6,000 - 60,000 ppm DUKE1992A

12-Lipoxygenase-Inhibitor MAB ; 5-Lipoxygenase-Inhibitor MAB ; Anesthetic 411 ; Antiacetylcholinesterase WIC ; Antibacterial 2 ug/ml; Anticholinesterase KCH ; Antiedemic CAN ; Antigingivitic JNP59:987 ; Antiinflammatory M11 ; Antimitotic WIC ; Antineoplastic LRN-JUL92 ; Antioxidant IC50=10 uM PM57:A49 ; Antiperiodontic 2 ug/ml JNP59:987 ; Antiplaque; Antiseptic 411 ; Antisuperoxidogenic IC50=16 nM PM57:A49 ; Antitrypanosomic NIG ; Antitumor 411 ; Antiviral 411 ; Calcium-Antagonist IC50=15 uM gpg K29404 ; Candidicide CAN ; Cardiotonic BP27:2555 ; CNS-Depressant LRN-JUL92 ; Diuretic KCH ; DNA-Intercalator 411 ; Emetic PJB1(2):276 ; Expectorant 411 ; Fungicide FT63(1):67 ; Gastrocontractant KCH ; Glaucomagenic JBH ; Gram(+)icide CAN ; Gram(-)icide LD50=292 (ivn rat) CAN ; Hepatotoxic 10 mg/kg ipr rat CAN42 ; Hypertensive DUKE1992B ; Hypotensive LRN-JUL92 ; Inotropic JBH ; Irritant WIC ; Lipase-Inhibitor MED ; Molluscicide POP:74 ; Myocardiocontractant KCH ; Nematicide 50-100 ug/ml NIG ; Occulotensive DUKE1992B ; Pesticide DUKE1992B ; Respirastimulant DUKE1992B ; Sialogogue DUKE1992B ; Sympatholytic DUKE1992B ; Trichomonicide NIG ; Vasomotor-Stimulant DUKE1992B


No activity reported.


Absorbent M29 ; Antidote (Iodine) JBH ; Antinesidioblastosic M29 ; Emollient M29 ; Poultice M29

The source of the experience

Dr Dukes plant database

Concepts, symbols and science items



Science Items

Activities and commonsteps






382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

414: Jim Duke's personal files

AEHD1:101: Jim Duke's personal files

AEHD1:99: Jim Duke's personal files

AHP136: Jim Duke's personal files

AHP137: Jim Duke's personal files

BP27:2555: Jim Duke's personal files

BPB17:458: Kubo, M., et al. 1994. Studies on Anti-cataract Drugs from Natural Sources. I. Effects of a Methanolic Extract and the Alkaloidal Components from Corydalis Tuber on in vit Aldose Reductase Activity. Biol Pharm Bull, 17(3): 458-459.

BRU: Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.

CAN: Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

CAN42: Jim Duke's personal files

CHP12:526: Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.

COX: Jim Duke's personal files

CPB38:2320: Jim Duke's personal files

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:222: Jim Duke's personal files

EMP6:235: Economic & Medicinal Plant Research, 6: 235.

FEL: Jim Duke's personal files

FT63(1):67: Jim Duke's personal files

GMJ: Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.

HH3: Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.

JAF48:1058: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JCE10:115: Jim Duke's personal files

JE27:243: Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.

JE32:161: Jim Duke's personal files

JE32:173: Jim Duke's personal files

JE38:1: Jim Duke's personal files

JNP59:987: Jim Duke's personal files

JOC58:5025: Fang, S. D., Wang, L. K., Hect, S. M. 1993. Inhibitors of DNA Topoisomerase I Isolated From the Roots of Zanthoxylum nitidum. J Org Chem, 58: 5025-5027.

K29404: Jim Duke's personal files

KCH: Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

KEB: Jim Duke's personal files

LEL: Lewis and Elvin-Lewis, Medical Botany, ca 1977

LRN-JUL91: Jim Duke's personal files

LRN-JUL92: Jim Duke's personal files

LRN-JUN87: Jim Duke's personal files

LRN-JUN89: Jim Duke's personal files

LRN-SEP91: Lawrence Review of Natural Products, Sep-91.

M11: Merck 11th Edition

M29: Martindale's 29th

MAB: Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.

MAR: Martindale's 28th

MED: Medline (post 1990 searches filed in my computer)

NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

PH2: Jim Duke's personal files

PIL: Jim Duke's personal files

PJB1(1): Jim Duke's personal files

PJB1(1):171: Jim Duke's personal files

PJB1(1):172: Jim Duke's personal files

PJB1(1):184: Jim Duke's personal files

PJB1(2):276: Jim Duke's personal files

PJB1(3):231: Jim Duke's personal files

PM57:A49: Jim Duke's personal files

PM60:421: Jim Duke's personal files

PM61:414: Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.

PMP25:62: Jim Duke's personal files

POP:117: Jim Duke's personal files

POP:74: Jim Duke's personal files

PR14:303: Jim Duke's personal files

PR4(4):132: Jim Duke's personal files

SPJ4:45: Al-Khalil, S. 1996. Inhibition of Lens Alkaloids Reductase by Protopine Alkaloids. Saudi Pharm J, 4(1): 45-47.

W&M: Werbach & Murray, 1994.

WIC: Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.

X11413687: Jim Duke's personal files

X15322253: Jim Duke's personal files

ppm = parts per million
tr = trace


Mon Nov 2 10:33:18 EST 2015