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Dr Duke's list of Chemicals and their Biological Activities in: Mitragyna speciosa KORTH. (Rubiaceae) -- Kratum

Identifier

019179

Type of Spiritual Experience

Background

A description of the experience

Chemicals and their Biological Activities in: Mitragyna speciosa KORTH. (Rubiaceae) -- Kratum


Chemicals

3-DEHYDROMITRAGYNINE Leaf 36 ppm; DUKE1992A

No activity reported.

AJMALICINE Leaf: DUKE1992A

Adrenolytic HH2 ; Antiadrenergic WOI ; Antiaggregant EMP5:344 ; Antidiuretic HDN ; Antihypertensive JBH ; Cerebrocirculant JBH ; Circulotonic HDN ; CNS-Depressant; Hypotensive HH2 ; Sympatholytic HH2 ; Tranquilizer JBH

CORYNANTHEIDALINE Leaf: DUKE1992A

No activity reported.

CORYNANTHEIDINE Leaf: DUKE1992A

No activity reported.

EPICATECHIN Leaf 150 ppm; DUKE1992A

Allelochemic IC100=1 mM 438 ; Anabolic X16028976 ; Antiaggregant IC94=200 ug/ml PR13:597 ; Antianaphylactic; Antibacterial MIC=>1,000 ug/ml; Anticomplementary 1/2 aspirin PM57:A48 ; Antidiabetic 30 mg/kg rat; AntiEBV EMP6:189 ; Antifeedant JCE27:251 ; Antihepatitic V&D ; AntiHIV EC50=2 ug/ml POP:270 ; Antihyperglycemic; Antiinflammatory; Antileukemic IC50=>10 ug/ml; Antilipoperoxidant PR13:597 ; Antimutagenic; Antioxidant 2.5 x Vit. E BO2 3/4 quercetin JAF49:3653 IC50=10.2 uM PR14:501 IC50=6.3 ug/ml CPB38:1049 ; Antiperoxidant JBH ; Antiviral; Cancer-Preventive 525 ; Cardiotonic DUKE1992B ; Choline-Sparing AFR27:149 ; Hepatotropic DUKE1992B ; Hypocholesterolemic AFR27:149 ; Hypoglycemic DUKE1992B ; Insulinogenic EMP6:170 ; Interleukin-1-alpha-Inhibitor X16248545 ; Interleukin-6-mRNA-Inhibitor X16248545 ; Lipoxygenase-Inhibitor IC50=140 uM PCF IC97=5 mM JAF38:688 ; NO-Inhibitor X16248545 ; Pancreatogenic DUKE1992B ; Peroxynitrite-Scavenger IC50=0.181 ug/ml JAF48:5768 ; Pesticide DUKE1992B ; Propecic PH2 ; TNF-alpha-Inhibitor X16248545 ; Xanthine-Oxidase-Inhibitor IC50=>40

ISOMITRAFOLINE Plant: DUKE1992A

No activity reported.

ISOMITRAPHYLLINE Leaf: DUKE1992A

Antileukemic IC50=45-60 uM/l PM59:A583 ; Immunostimulant PAT.4,844,901 ; Phagocytotic

ISOSPECIOFOLINE Plant: DUKE1992A

No activity reported.

MITRACILIATINE Leaf 32 ppm; DUKE1992A

No activity reported.

MITRAGYNALINE Leaf: DUKE1992A

No activity reported.

MITRAGYNINE Leaf 86 ppm; DUKE1992A

Analgesic W&W ; Anesthetic DUKE1992B ; CNS-Stimulant DUKE1992B ; Hypotensive DUKE1992B ; Myorelaxant DUKE1992B ; Vasodilator DUKE1992B

MITRAGYNOL Plant: DUKE1992A

No activity reported.

MITRAPHYLLINE Leaf: DUKE1992A

Anesthetic IWU ; Antihypertensive IWU ; Antileukemic IC50=60-120 uM/l PM59:A583 ; Cardiodepressant IWU ; CNS-Depressant JBH ; Hypotensive JBH ; Immunostimulant PAT.4,844,901 ; Myocontractant IWU ; Myorelaxant DUKE1992B ; Pesticide DUKE1992B ; Protisticide IWU ; Vasodilator DUKE1992B

MITRASPECINE Seed: DUKE1992A

No activity reported.

MITRAVERSINE Plant: DUKE1992A

No activity reported.

PAYNANTHEINE Leaf 50 ppm; DUKE1992A

No activity reported.

RHYNCHOPHYLLINE Leaf: DUKE1992A

Anesthetic IWU ; Antiaggregant PH2 ; Antidementia X12895681 ; Antiexcitotoxic X12895681 ; Antihypertensive; Antiischemic X12895681 ; Antioxidant X12895681 ; Antipyretic JBH ; Antiradicular X12895681 ; Antithrombotic PH2 ; Calcium-Antagonist 10.1 uM rat M18481 ; Calcium-Blocker X12546715 ; Cardiodepressant IWU ; Dopaminergic PH2 ; Febrifuge PJB1(2):284 ; Hypotensive; Myocontractant IWU ; Neuroparalytic DUKE1992B ; Protisticide IWU ; Sedative DUKE1992B ; Serotonergic PH2 ; Uterotonic DUKE1992B ; Vasodilator X14668978

ROTUNDIFOLINE Plant: DUKE1992A

No activity reported.

SPECIOCILIATINE Leaf 30 ppm; DUKE1992A

Analgesic DUKE1992B ; Antitussive DUKE1992B

SPECIOFOLINE Leaf: DUKE1992A

No activity reported.

SPECIOGYNINE Leaf 44 ppm; DUKE1992A

No activity reported.

SPECIOPHYLLINE Leaf: DUKE1992A

Antileukemic IC50=60 uM/l PM59:A583

STIPULATINE Leaf: DUKE1992A

No activity reported.

UNCARINE-D Plant: DUKE1992A

Cytotoxic ED50=36 526

The source of the experience

Dr Dukes plant database

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Kratom

Suppressions

Mitragyna speciose - Kratom

Commonsteps

References

438: Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

526: Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp.

AFR27:149: Singleton, V.L. 1981. Naturally Occurring Food Toxicants: Phenolic Substances of Plant Origin Common in Foods. Advances in Food Research 27: 149-217.

BO2: Jim Duke's personal files

CPB38:1049: Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:344: Jim Duke's personal files

EMP6:170: Economic & Medicinal Plant Research, 6: 170.

EMP6:189: Economic & Medicinal Plant Research, 6: 189.

HDN: Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

HH2: Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.

IWU: Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.

JAF38:688: Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.

JAF48:5768: Jim Duke's personal files

JAF49:3653: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JCE27:251: Jim Duke's personal files

M18481: Jim Duke's personal files

PAT.4,844,901: Jim Duke's personal files

PCF: Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.

PH2: Jim Duke's personal files

PJB1(2):284: Jim Duke's personal files

PM57:A48: Jim Duke's personal files

PM59:A583: Jim Duke's personal files

POP:270: Jim Duke's personal files

PR13:597: Jim Duke's personal files

PR14:501: Jim Duke's personal files

V&D: Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.

W&W: Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176)

WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.

X12546715: Jim Duke's personal files

X12895681: Jim Duke's personal files

X14668978: Jim Duke's personal files

X16028976: Jim Duke's personal files

X16248545: Jim Duke's personal files

ppm = parts per million
tr = trace