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Observations placeholder

DPP is 'like cocaine'

Identifier

002103

Type of Spiritual Experience

Hallucination

Number of hallucinations: 1

Background

Diphenylpyraline  - DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first generation H1 receptor antagonist.  It is marketed in Europe for the treatment of allergies.  DPP has also been found to act as a dopamine reuptake inhibitor

A description of the experience

Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties - Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.

Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood.

Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse nucleus accumbens slices showed that DPP (10 microM) markedly inhibited dopamine uptake. There was a 20-fold increase in apparent Km for dopamine uptake, while Vmax was unchanged. Microdialysis experiments demonstrated that DPP (5 mg/kg, i.p.) elevated extracellular dopamine levels (approximately 200%) in mouse nucleus accumbens. DPP (5 and 10 mg/kg) also induced locomotor activation.

All of the effects of DPP were comparable with those of cocaine. Taken together, these results indicate that DPP acts as a competitive dopamine transporter inhibitor similar to cocaine

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Anti-histamines
Reuptake inhibitors

Commonsteps

References