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Citrus fruits as an antidote to Colchicine

Identifier

016802

Type of Spiritual Experience

Background

This is a very complex observation.

For reasons we are unable to understand, doctors have decided that the poisonous plant autumn crocus makes a good medicine for gout, pericarditis [inflammation of the heart lining] , IBS and canker sores.

Colchicine poisoning has been compared to arsenic poisoning. Symptoms start 2 to 5 hours after the toxic dose has been ingested and include burning in the mouth and throat, fever, vomiting, diarrhea, abdominal pain, and kidney failure. These symptoms may set in as many as 24 hours after exposure. Onset of multiple-system organ failure may occur within 24 to 72 hours. This includes hypovolemic shock due to extreme vascular damage and fluid loss through the gastrointestinal tract, which may cause death. In addition, sufferers may experience kidney damage that causes low urine output and bloody urine, low white blood cell counts (persisting for several days), anemia, muscular weakness, and respiratory failure. Recovery may begin within six to eight days.

If the figures from ehealthme are an indicator it is responsible for a number of deaths, for example:

On Jun, 20, 2015: 1,366 people reported to have side effects when taking Colchicine. Among them, 10 people (0.73%) have Death Of Child.

Trend of Death of child in Colchicine reports

On Jun, 20, 2015: 1,366 people reported to have side effects when taking Colchicine. Among them, 10 people (0.73%) have Death Of Spouse.

Trend of Death of spouse in Colchicine reports

Time on Colchicine when people have Death of spouse * :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Death of spouse 100.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%

 

What this paper shows, although the researchers did not set out to show this, is that citrus fruits appear to be vey good at handling poisons before they enter th body.  Here oranges and grapefruit succeeded in counteracting the poisoning undertaken by the doctors on their patients, rendering the drug a lot less harmful.

 

 

 

 

A description of the experience

Clin Ther. 2012 Oct;34(10):2161-73. doi: 10.1016/j.clinthera.2012.08.007. Epub 2012 Aug 31.

Effects of grapefruit and Seville orange juices on the pharmacokinetic properties of colchicine in healthy subjects.

Wason S1, DiGiacinto JL, Davis MW.

  • 1URL Pharma, Inc, Philadelphia, Pennsylvania, USA. swason@urlpharma.com

 

BACKGROUND:

The labeling for colchicine (indicated for acute gout flares or prophylaxis) includes strict advisories regarding drug-drug and drug-food interactions, including warnings against consuming grapefruit or grapefruit juice during treatment. Two of the furocoumarins in grapefruit juice and Seville orange juice can inhibit intestinal cytochrome P450 (CYP) isozyme 3A4 and P-glycoprotein (involved in colchicine metabolism and transport). Severe toxicities in patients consuming these juices while taking other drugs metabolized through these pathways have been reported.

OBJECTIVE:

Two Phase I studies assessed the effects of multiple daily consumptions of Seville orange juice or grapefruit juice on the pharmacokinetic properties of colchicine in healthy volunteers.

METHODS:

Healthy volunteers were enrolled in 2 open-label, Phase I studies. Undiluted juice (240 mL) was administered twice daily for 4 days. Pharmacokinetic data were obtained following a single 0.6-mg dose of colchicine before the administration of juice and again following a single 0.6-mg dose of colchicine on the final day of juice administration. In each study, blood samples for pharmacokinetics were collected before dosing with colchicine and at 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, and 24 hours postdose. All subjects were monitored for adverse events (AEs) throughout the confinement portion of the study and were queried at the outpatient visits. AEs were coded according to corresponding MedDRA-coded system organ classes.

RESULTS:

Forty-four subjects received either grapefruit juice (72.7% male; 90.9% white) or Seville orange juice (62.5% female; 100% white). Although it is considered to be a moderate concentration-dependent CYP3A4 inhibitor, grapefruit juice did not significantly affect the pharmacokinetic parameters of colchicine. When colchicine was administered with Seville orange juice, a moderate inhibitor, C(max) and AUC were decreased by ∼24% and ∼20%, respectively. Seville orange juice also caused, on average, a 1-hour delay in T(max). Colchicine in combination with grapefruit or Seville orange juice was well tolerated. There were no significant treatment-related AEs reported, and the most likely AEs were general gastrointestinal events.

CONCLUSIONS:

In contrast to label warnings based on the literature, grapefruit juice did not affect the pharmacokinetics of colchicine. Seville orange juice paradoxically reduced absorption of colchicine and increased T(max), but the clinical significance of this is unknown. Contrary to the expected effects of inhibiting the enzymes that metabolize colchicine, neither juice increased exposure to colchicine. However, the absence of a positive control in these studies dictates that caution should be used when applying these results clinically. ClinicalTrials.gov identifiers: NCT00960193 and NCT00984009.

Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved.

PMID:  22940371

The source of the experience

PubMed

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