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Blackberries and colon cancer

Identifier

005364

Type of Spiritual Experience

Background

A description of the experience

 

J Med Food. 2007 Jun;10(2):258-65. Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Dai J, Patel JD, Mumper RJ. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.

Blackberries are rich in polyphenols, including anthocyanins. Polyphenols are hypothesized to have biological activities that may impact positively on human health. In these studies, an anthocyanin-rich extract from Hull blackberries grown in Kentucky was obtained and fully characterized in terms of total anthocyanin and phenolic content, polymeric color, anthocyanin composition, and total antioxidant capacity. In vitro cell culture studies showed that the blackberry extract inhibited HT-29 colon tumor cell growth in a concentration-dependent manner with 49.2 microg of total anthocyanins/mL inhibiting HT-29 cell growth up to 66% at 72 hours. Likewise, in a concentration-dependent manner, total anthocyanin concentrations in the range of 0-40 microg/mL suppressed both high-dose (10 microg/mL) and low-dose (0.1 microg/mL) lipid A-induced interleukin-12 release from mouse bone marrow-derived dendritic cells. These results suggest that Hull blackberry extract (HBE) has potent antioxidant, antiproliferative, and anti-inflammatory activities and that HBE-formulated products may have the potential for the treatment and/or prevention of cancer and/or other inflammatory diseases.

PMID: 17651061

The source of the experience

PubMed

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Activities

Overloads

Cancer
Colon cancer

Suppressions

Blackberries

Commonsteps

References