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G Ital Med Lav Ergon. 2012 Jan-Mar;34(1):16-8. [Shoe factory workers, solvents and health].  [Article in Italian] Foà V, Martinotti I. Centro di Riferimento PPTP Clinica del Lavoro Luigi Devoto, e Fondazione (I.R.C.C.S.) Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena e Università degli Studi, Milano, Italy. vito.foa@alice.it

Exposure to organic solvents in footwear manufacturing industry came from the glues used adhering the shoe parts to each other. Benzene was the first solvent used in shoe factories until the evidence of its capacity to cause leukaemia.

Then, the demonstration that exposure to n-hexane was related to distal polyneuropathy limited the use of this substance.

After that, results of neurotoxicological studies conducted on workers exposed to different mixtures of organic solvents make necessary prevention measure directed to a progressive reduction of air dispersion of these chemicals.

Today exposure to solvents in workplaces is regulated by health based exposure limit values that should warranty absence of central nervous system effects.

One of the most important rules of occupational medicine is verify that these exposure levels are really health protective also for workers with increased susceptibility.

PMID: 22697025