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Mirtazapine (originally branded Remeron, many generics) is an atypical antidepressant with noradrenergic and specific serotonergic activity. It blocks the α2 adrenergic auto- and heteroreceptors (enhancing norepinephrine release), and selectively antagonizes the 5-HT2 serotonin receptors in the central and peripheral nervous system. It also enhances serotonin neurotransmission at the 5-HT1 receptor and blocks the histaminergic (H1) and muscarinic receptors. Mirtazapine is not a serotonin or norepinephrine reuptake inhibitor but may increase serotonin and norepinephrine by other mechanisms of action.

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) introduced by Organon International in the United States in 1996, and is used primarily in the treatment of depression. It is also commonly used as an anxiolytic, hypnotic, antiemetic and appetite stimulant. In structure, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA) and is the 6-aza analogue of mianserin. It is also racemic – occurs as a combination of both (R)-(−)- and (S)-(+)-stereoisomers, both of which are active.

Its patent expired in 2004, so generic versions are available.

Most common Mirtazapine side effects from eHealthme

• Stress and anxiety - (1,454 reports)
• Fatigue - (1,407 reports)
• Nausea - (1,295 reports)
• Depression - (1,288 reports)
• Dizziness - (1,213 reports)
• Completed suicide - (1,178 reports)
• Breathing difficulty - (1,158 reports)
• Weakness - (1,085 reports)
• Fall - (1,056 reports)
• Diarrhea - (1,052 reports)

On Jan, 29, 2017  26,739 people reported to have side effects when taking Mirtazapine.
Among them, 810 people (3.03%) have Death

On Jan, 14, 2017  26,739 people reported to have side effects when taking Mirtazapine.  Among them, 395 people (1.48%) have Hallucination

On Jan, 18, 2017  26,739 people reported to have side effects when taking Mirtazapine.  Among them, 186 people (0.7%) have Hallucination, Auditory

On Feb, 07, 2017 26,739 people reported to have side effects when taking Mirtazapine.  Among them, 1 person (0.0%) has Hallucination, Olfactory

On Feb, 07, 2017  26,739 people reported to have side effects when taking Mirtazapine.  Among them, 3 people (0.01%) have Hallucination, Tactile

On Jan, 20, 2017  26,739 people reported to have side effects when taking Mirtazapine.  Among them, 548 people (2.05%) have Hallucinogen Abuse