J Nerv Ment Dis. 2010 May;198(5):334-8. doi: 10.1097/NMD.0b013e3181da852a.

Comorbidities of obsessive and compulsive symptoms in Huntington's disease.

Anderson KE, Gehl CR, Marder KS, Beglinger LJ, Paulsen JS; Huntington's Study Group.

Collaborators (129)

Abstract

Although current reports document a high rate of obsessive and compulsive symptoms (O/Cs) in Huntington's disease (HD), there have been no studies published that have made an attempt to identify comorbidities of O/Cs in HD. We examined O/Cs in 1642 individuals with a diagnosis of HD. Of those endorsing significant O/Cs (27.2%), nearly one-quarter reported obtaining treatment for obsessive compulsive disorder.

Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hallucinations.

Participants with the most severe O/Cs and worse performance on the Stroop task, a measure of executive function. Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan.

PMID:

20458194