Phytother Res. 2010 Apr;24(4):583-6. doi: 10.1002/ptr.2990.

Effects of acacia honey on wound healing in various rat models.

Iftikhar F1, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M.

• 1Department of Honey Bee Research, National Agricultural Research Council, PO NARC, Park Road, Islamabad, Pakistan.

Abstract

Honey is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a significant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.

Copyright (c) 2009 John Wiley & Sons, Ltd.

PMID:

19813239