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Vaginally administered estrogens are estrogens that are delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens.

Vaginally administered estrogen are usually used to treat some menopausal symptoms that are isolated to the vagina, vulva and urethra.  It will not protect a woman against osteoporosis nor will it alleviate the hot flushes and hormonal imbalance caused by menopause.

Side effects

Most of the vaginally administered estrogens are synthetic and therefore cause the following side effects

Serious side effects:

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• sudden numbness or weakness, especially on one side of the body;
• sudden severe headache, confusion, problems with vision, speech, or balance;
• pain, swelling, warmth, or redness in one or both legs;
• abnormal vaginal bleeding;
• migraine headache;
• pain, swelling, or tenderness in your stomach;
• confusion, problems with memory or concentration;
• jaundice (yellowing of the skin or eyes);
• swelling in your hands, ankles, or feet; or
• a breast lump.

Less serious side effects may include:

• mild nausea, vomiting, bloating, stomach cramps;
• breast pain, tenderness, or swelling;
• freckles or darkening of facial skin;
• increased hair growth, loss of scalp hair;
• changes in weight or appetite;
• problems with contact lenses;
• vaginal itching or discharge;
• changes in your menstrual periods, decreased sex drive; or
• headache, nervousness, dizziness, tired feeling.

On Jan, 23, 2016: 1,426 people reported to have side effects when taking Vagifem. Among them, 4 people (0.21%) have Hallucination.

On Feb, 18, 2016: 1,427 people reported to have side effects when taking Vagifem. Among them, 8 people (0.56%) have Death.