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Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius and used to treat various types of bacterial infections, particularly Gram-negative infections.

Side effects

Like other aminoglycosides, tobramycin is ototoxic: it can cause hearing loss, or a loss of equilibrioception, or both in genetically susceptible individuals. These individuals carry a normally harmless genetic mutation that allows aminoglycosides such as tobramycin to affect cochlear cells. Aminoglycoside-induced ototoxicity is generally irreversible.

As with all amino glycosides, tobramycin is also nephrotoxic, it can damage or destroy the tissue of the kidneys . This effect can be particularly worrisome when multiple doses accumulate over the course of a treatment or when the kidney concentrates urine by increasing tubular reabsorption during sleep. Adequate hydration may help prevent excess nephrotoxicity and subsequent loss of renal function. For these reasons parenteral tobramycin needs to be carefully dosed by body weight, and its serum concentration monitored. Tobramycin is thus said to be a drug with a narrow therapeutic index.

On Jan, 19, 2016: 229 people reported to have side effects when taking Tobrex. Among them, 32 people (13.97%) have Hallucination.

On Feb, 11, 2016: 229 people reported to have side effects when taking Tobrex. Among them, 1 people (0.44%) has Death.