Observations placeholder
Orencia
Identifier
019815
Type of Spiritual Experience
Background
A description of the experience
Abatacept (marketed as Orencia) is an immunosuppressant.
"it is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an antigen presenting cell must present two signals to the T cell. One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2). Abatacept binds to the CD80 and CD86 molecule, and prevents the second signal. Without the second signal, the T cell can't be activated. "
Abatacept is licensed in the United States for the treatment of rheumatoid arthritis in the case of inadequate response to anti-TNFα therapy.
On Dec, 13, 2016 16,650 people reported to have side effects when taking Orencia.
Among them, 17 people (0.1%) have Hallucination
On Dec, 25, 2016 16,650 people reported to have side effects when taking Orencia.
Among them, 343 people (2.06%) have Death
Time on Orencia when people have Death :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Death | 22.22% | 22.22% | 25.93% | 14.81% | 14.81% | 0.00% | 0.00% |
Top conditions involved for these people :
- Rheumatoid arthritis (57 people, 45.60%)
On Jan, 08, 2017 16,650 people reported to have side effects when taking Orencia.
Among them, 3 people (0.02%) have Foetal Death