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Gemtuzumab ozogamicin (marketed as Mylotarg) is a drug-linked monoclonal antibody (an antibody-drug conjugate) that was used to treat acute myelogenous leukemia from 2000 to 2010. It was withdrawn from market in June 2010 when a clinical trial showed the drug increased patient death and added no benefit over conventional cancer therapies.

Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins. CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells. In the United States, it was approved under an accelerated-approval process by the FDA in 2000 for use in patients over the age of 60 with relapsed acute myelogenous leukemia (AML); or those who are not considered candidates for standard chemotherapy

Within the first year after approval, the FDA required a black box warning be added to Gemtuzumab packaging. The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. Later the onset of VOD was shown to occur at increased frequency in Gemtuzumab patients even following bone marrow transplantation. The drug was discussed in a 2008 JAMA article, which criticized the inadequacy of postmarketing surveillance of biologic agents

Common side effects of administration included shivering, fever, nausea and vomiting. Serious side effects included severe myelosuppression (suppressed activity of bone marrow, which is involved in formation of various blood cells [found in 98% of patients]), disorder of the respiratory system, tumor lysis syndrome, Type III hypersensitivity, venous occlusion, and death.

On Jan, 7, 2016: 3,116 people reported to have side effects when taking Mylotarg. Among them, 9 people (0.29%) have Hallucination.

Time on Mylotarg when people have Hallucination  :

On Jan, 7, 2016: 3,116 people reported to have side effects when taking Mylotarg. Among them, 25 people (0.80%) have Death.

Time on Mylotarg when people have Death  :

Gender of people who have Death when taking Mylotarg  :

Age of people who have Death when taking Mylotarg  :

Top conditions involved for these people  :

1. Acute myeloid leukaemia (16 people, 64.00%)
2. Acute myeloid leukaemia recurrent (4 people, 16.00%)
3. Prophylaxis (2 people, 8.00%)
4. Myelodysplastic syndrome (1 people, 4.00%)