Mutat Res. 1990 Jun;244(2):129-34.

Inhibitory action of peony root extract on the mutagenicity of benzo[a]pyrene.

Sakai Y1, Nagase H, Ose Y, Kito H, Sato T, Kawai M, Mizuno M.

• 1Gifu Prefectural Institute of Public Health, Japan.

Abstract

The inhibitory effects of peony root extract on the mutagenicity of benzo[a]pyrene (B [a]p) have been investigated in the Salmonella typhimurium reversion test. Four kinds of experiments were performed: direct chemical reaction (1) between peony root extract and B [a]p, and (2) between peony root extract and active metabolite(s) of B [a]p, (3) inhibition of metabolic processes of B[a]p with S9 mix, and (4) inhibition of activation on mutagenicity. Peony root extract interfered with the action of enzymes in the S9 mix, and inactivated the activity of B[a]p metabolites. The bio-antimutagenic effect was assayed by reversion in Salmonella typhimurium TA98 and TA100.

PMID:

2192283