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Ciclosporin, also spelled cyclosporine and cyclosporin, and known as ciclosporin A cyclosporine A, or cyclosporin A (often shortened to CsA) is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells

Treatment may be associated with a number of potentially serious adverse drug reactions (ADRs).

ADRs can include enlargement of the gums, convulsions, peptic ulcers, pancreatitis, fever, vomiting, diarrhea, confusion, hypercholesterolemia, dyspnea, numbness and tingling particularly of the lips, pruritus, high blood pressure, potassium retention possibly leading to hyperkalemia, kidney and liver dysfunction (nephrotoxicity[13] and hepatotoxicity), burning sensations at finger tips, and an increased vulnerability to opportunistic fungal and viral infections. In short, it is nephrotoxic, neurotoxic, causes hypertension (due to renal vasoconstriction and increased sodium reabsorption), and increases the risk of squamous cell carcinoma and infections. It also causes enlargement of the gums and increased hair growth which is not seen with tacrolimus (another calcineurin inhibitor).

On Dec, 21, 2015: 318 people reported to have side effects when taking Gengraf. Among them, 3 people (0.94%) have Hallucination.

 On Dec, 21, 2015: 318 people reported to have side effects when taking Gengraf. Among them, 7 people (2.20%) have Death.