J Ethnopharmacol. 2014 Aug 8;155(1):320-5. doi: 10.1016/j.jep.2014.05.035. Epub 2014 May 29.

Anti-influenza virus activity of the ethanolic extract from Peperomia sui.

Yang CH1, Tan DH2, Hsu WL2, Jong TT3, Wen CL4, Hsu SL5, Chang PC6.

ETHNOPHARMACOLOGICAL RELEVANCE:

Peperomia sui Lin and Lu (Peperomia sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explored the activity of Peperomia sui against influenza virus infections. This study was carried out to evaluate the anti-influenza virus activity and the potential virucidal effect of the ethanolic extract of Peperomia sui (PSE).

METHODS:

The anti-H6N1 avian influenza viral activity of PSE against the influenza virus A/Chicken/TW/0518/2011 (H6N1) in chicken fibroblast DF-1 cells was evaluated by cell viability assay, hemagglutination assay, neuraminidase activity assay, indirect immunofluorescence assay and quantitative RT-PCR assay.

RESULTS:

PSE significantly increased the viability of cells that were infected by the H6N1 virus. PSE also suppressed the synthesis of viral nucleoprotein (NP), and inhibited the growth of the virus in DF-1 cells. Further, PSE inhibited the neuraminidase activity of H6N1 virus.

CONCLUSIONS:

The findings of this study provide important information for the exploitation and utilization of Peperomia sui in treatment of influenza infection.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Antiviral activity; Hemagglutination; Influenza virus; Peperomia sui

PMID: 24882727