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Timolol is a non-selective beta-adrenergic receptor antagonist indicated for treating glaucoma.  In its ophthalmic form it is used to treat open-angle and occasionally secondary glaucoma by reducing aqueous humour production through blockage of the beta receptors on the ciliary epithelium.

The pharmacological mechanism by which it actually does this is still unknown [sic]. It was the first beta-blocker approved for topical use in treatment of glaucoma in the USA (1978). However, there are short-term escape and long-term drift effects in some patients. That is, tolerance develops. May reduce extent of diurnal IOP curve up to 50%. IOP higher during sleep. 5-10x more potent beta-blocker than propranolol.

On Sep, 1, 2015: 3,650 people reported to have side effects when taking Timolol maleate. Among them, 28 people (0.77%) have Hallucination.

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On Sep, 1, 2015: 2,959 people reported to have side effects when taking Timoptic. Among them, 34 people (1.15%) have Hallucination.

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On Sep, 1, 2015: 76 people reported to have side effects when taking Istalol. Among them, 1 people (1.32%) has Hallucination.