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In vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin
Identifier
017222
Type of Spiritual Experience
Background
A description of the experience
Biomed Res Int. 2015;2015:292797. doi: 10.1155/2015/292797. Epub 2015 Mar 11.
In vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin.
de Oliveira DR1, Tintino SR2, Braga MF2, Boligon AA3, Athayde ML3, Coutinho HD2, de Menezes IR4, Fachinetto R5.
- 1Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil.
- 2Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri (URCA), 63100-000 Crato, CE, Brazil.
- 3Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil.
- 4Laboratório de Microbiologia e Biologia Molecular, Departamento de Química Biológica, Universidade Regional do Cariri, 63100-000 Crato,CE, Brazil.
- 5Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil ; Programa de Pós-Graduaçãoo em Farmacologia, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil.
Abstract
Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent.
The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice.
Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL.
The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains.
Silymarin and silibinin appear to have promising potential, showing synergistic properties, which should prompt further studies along this line.
PMID: 25866771