Observations placeholder
Atharvaveda - VI 109 The pepper corn as a cure for wounds
Identifier
015853
Type of Spiritual Experience
Background
nfect Agent Cancer. 2014 Dec 16;9(1):43. doi: 10.1186/1750-9378-9-43. eCollection 2014. Inhibitory effect of piperine on Helicobacter pylori growth and adhesion to gastric adenocarcinoma cells. Tharmalingam N1, Kim SH2, Park M1, Woo HJ1, Kim HW1, Yang JY1, Rhee KJ1, Kim JB1.
- 1Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, Republic of Korea.
- 2Department of Clinical Laboratory Science, Semyung University, Jaecheon, Republic of Korea.
BACKGROUND: Piperine is a compound comprising 5-9% of black pepper (Piper nigrum), which has a variety of biological roles related to anticancer activities. Helicobacter pylori has been classified as a gastric carcinogen, because it causes gastritis and gastric cancer by injecting the virulent toxin CagA and translocating VacA. The present study investigated the inhibitory action of piperine on H. pylori growth and adhesion.
RESULTS: Administrated piperine suppressed the level of H. pylori adhesion to gastric adenocarcinoma cells in a dose dependent manner and the inhibition was statistically significant as determined by Student's t-test. In addition, piperine treatment effects on the flagellar hook gene flgE and integral membrane component of the export apparatus gene flhA expression to be suppressed and piperine diminished the H. pylori motility.
CONCLUSIONS: flhA, encodes an integral membrane component of the export apparatus, which is also one of the regulatory protein in the class 2 genes expression and flgE is one of them that encodes hook part of the flagella. Suppression of both genes, leads to less motility results in the organism attracted less towards to the gastric epithelial cells might be the possible reason in the adhesion inhibition. To our knowledge, this is the first report published on the inhibitory effects of piperine against the adhesion of H. pylori to gastric adenocarcinoma cells.
PMID:25584066
A description of the experience
The Atharvaveda translated by Maurice Bloomfield
The pepper corn cures the wounds that have been struck by 'missiles'
It also cures the wounds from stabs
The gods decreed
'Powerful to secure life this plant shall be'.
The pepper corns spake to one another as they came out, after having been created
'He whom we shall find as yet alive, that man shall not suffer harm'.
The Asuras did dig thee into the ground
the gods cast thee up again
as a cure for disease produced by wind
moreover as a cure for wounds struck by 'missiles'.