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Overview

Tamoxifen is a first-line hormonal treatment of ER-positive metastatic breast cancer. It is used for breast cancer risk reduction in women at high risk, and as adjuvant treatment of axillary node-negative and node-positive, ductal carcinoma in situ. Tamoxifen treatment is also useful in the treatment of bone density and blood lipids in postmenopausal women. Adverse effects include hot flushes and more serious is two to three times higher relative risk of developing endometrial cancer compared to women of an age-matched population.

Detail

Tamoxifen is used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausal women. And is the most common hormone treatment for male breast cancer. It is also approved by the FDA for the “prevention of breast cancer in women at high risk of developing the disease”.[

Tamoxifen has been used to treat premature puberty and the consequences of premature puberty. However, one in vitro study in 2007 and later an in vivo study in 2008 have shown that tamoxifen induces apoptosis in growth plate chondrocytes, reduces serum IGF-I levels and causes persistent retardation of longitudinal and cortical radial bone growth in young male rats, leading the researches to express concern giving tamoxifen to growing individuals.

Tamoxifen is used to treat infertility in women with anovulatory disorders.

Tamoxifen is used to prevent estrogen-related gynecomastia, resulting from elevated estrogenic levels. Tamoxifen is also sometimes used to treat or prevent gynecomastia in sex offenders undergoing temporary chemical castration.

Tamoxifen has also been used in the treatment of mania in patients with bipolar disorder by blocking protein kinase C (PKC), an enzyme that regulates neuron activity in the brain.

On Mar, 11, 2015: 8,728 people reported to have side effects when taking Tamoxifen citrate. Among them, 63 people (0.72%) have Hallucination.

Time on Tamoxifen citrate when people have Death  :