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Surgery causes hallucinations

Identifier

006349

Type of spiritual experience

Hallucination

Background

The acetylcholine [stress inhibitor] is only part of the problem.  The main part is the hypoxia this all causes

 

A description of the experience

Med Hypotheses. 2007;68(1):194-6. Epub 2006 Sep 18. Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment. Hála M. Centre of Cardiovascular Surgery and Transplantation, Anaesthesiology and Intensive Care, Pekarská 53, 656 91 Brno, Czech Republic. haalis@seznam.cz

Postoperative delirium represents a serious complication after major surgery. Patients suffer from anxiety, hallucinations and delusions, and have higher postoperative morbidity and mortality.

Generally, the role of acetylcholine deficiency in delirium pathophysiology is widely accepted. How this pathologic state evolves in the postoperative period is the topic of this paper.

Systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment. The most relevant pathologies include leukocyte adhesion to vessel lining, endothelial cell swelling, perivascular oedema, narrowing of capillar diameters, and lowered functional capillary density.

These morphological changes lead to a decrease of nutritive perfusion and to longer diffusion distance for oxygen.

Because acetylcholine synthesis is especially sensitive to low oxygen tension, symptoms of its deficiency readily develop. Therapeutic tools to modulate excessive inflammation are available, therefore new strategies of delirium treatment should be implemented in clinical praxis, as well as in preventive measures.

PMID: 16979300

The source of the experience

PubMed

Activities