Observations placeholder
Sinemet [Carbidopa, levodopa]
Identifier
001526
Type of Spiritual Experience
Background
A description of the experience
Carbidopa/levodopa is the combination of carbidopa and levodopa and is used is used in the treatment of Parkinson’s disease and Dopa-Responsive Dystonia (DRD).
It is sold under several brand names, including Sinemet , Parcopa , Atamet and Co-careldopa, Caridopa and Levedopa Celebrex .
Most common Carbidopa and levodopa side effects from eHealthme
- Fall - (173 reports)
- Parkinson's disease - (172 reports)
- Dyskinesia - (156 reports)
- Drug ineffective - (139 reports)
- Tremor - (129 reports)
- Nausea - (124 reports)
- Hallucinations - (105 reports)
- Fatigue - (103 reports)
- Weakness - (96 reports)
- Depression - (91 reports)
Dopamine functions as a neurotransmitter, activating the five known types of dopamine receptors—D1, D2, D3, D4, and D5—and their variants. Clinically, it is available as an intravenous medication acting on the sympathetic nervous system, producing effects such as increased heart rate and blood pressure. However, because dopamine cannot cross the blood-brain barrier, dopamine given as a drug does not directly affect the central nervous system. To increase the amount of dopamine in the brains of patients with diseases such as Parkinson's disease and dopa-responsive dystonia, L-DOPA/levodopa (the precursor of dopamine), is often given because it crosses the blood-brain barrier relatively easily.
The Carbidopa inhibits DOPA Decarboxylase or DDC - an enzyme important in the biosynthesis of L-DOPA to Dopamine. Used in tandem with L-DOPA , it prevents the conversion of L-DOPA to dopamine peripherally. This reduces the side effects caused by dopamine on the periphery, as well as increasing the concentration of L-DOPA and dopamine in the brain.
Despite this long winded explanation, I think you can see it is aimed at boosting the activity at all dopamine receptors.
On Feb, 01, 2017 2,357 people reported to have side effects when taking Carbidopa And Levodopa. Among them, 105 people (4.45%) have Hallucination
On Jan, 12, 2017 2,357 people reported to have side effects when taking Carbidopa And Levodopa. Among them, 12 people (0.51%) have Hallucination, Auditory
On Feb, 02, 2017 107 people reported to have side effects when taking Parcopa. Among them, 3 people (2.8%) have Hallucination
On Feb, 02, 2017 1,539 people reported to have side effects when taking Sinemet Cr. Among them, 48 people (3.12%) have Hallucination
On Mar, 23, 2015: 10,445 people reported to have side effects when taking Sinemet. Among them, 529 people (5.06%) have Hallucination.
Time on Sinemet when people have Hallucination :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Hallucination | 31.37% | 17.65% | 3.92% | 29.41% | 11.76% | 3.92% | 1.96% |
Gender of people who have Hallucination when taking Sinemet :
| Female | Male | |
| Hallucination | 38.86% | 61.14% |
Age of people who have Hallucination when taking Sinemet :
| 0-1 | 2-9 | 10-19 | 20-29 | 30-39 | 40-49 | 50-59 | 60+ | |
| Hallucination | 0.00% | 0.00% | 0.19% | 0.38% | 0.76% | 1.33% | 7.02% | 90.32% |
Severity of Hallucination when taking Sinemet :
| least | moderate | severe | most severe | |
| Hallucination | 14.29% | 28.57% | 28.57% | 28.57% |
On Mar, 6, 2015: 10,445 people reported to have side effects when taking Sinemet. Among them, 287 people (2.75%) have Death.
Time on Sinemet when people have Death :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Death | 20.69% | 20.69% | 13.79% | 10.34% | 27.59% | 3.45% | 3.45% |
On Mar, 31, 2015: 1,451 people reported to have side effects when taking Sinemet cr. Among them, 55 people (3.79%) have Death.
Time on Sinemet cr when people have Death :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Death | 0.00% | 100.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |