Observations placeholder

Clonazepam  and Clonazepam teva - is a benzodiazepine with very potent anxiolytic properties. It is marketed under the trade-names Klonopin  and Ravotril, Rivotril or Rivatril. Clonazepam has an unusually long half life of 18–50 hours, making it generally considered to be among the long-acting benzodiazepines. 

 The pharmacological property of clonazepam as with other benzodiazepines is the enhancement of the neurotransmitter GABA via modulation of the GABA_A receptor.  And like all the benzodiazepines it has an impressive record for producing involuntary hallucinations and an equally impressive record of supporting voluntary ones in the so called ‘recreational community’.  You will find a  vast number of experiences on 

Having said this, it is not as popular as Lorazepam in the ‘recreational community’, partly because of its long half life and also because it is not quite as quick acting.  Peak blood concentrations of 6.5–13.5 ng/mL are reached within abou 1–2 hours following a single 2 mg oral dose of micronized clonazepam in healthy adults. In some individuals, however, peak blood concentrations take 4–8 hours.

Medically, it  has anticonvulsant, muscle relaxant, and anxiolytic properties. Classified as a high potency benzodiazepine, it  has been used however, for the following illnesses, although with severe reservations in some parts of the medical fraternity because of its record – as with all benzodiazepines – of producing dependence and tolerance and the fact that the list includes groups of people who should not be given benzodiazepines. 

• Epilepsy – one off treatment of seizure
• Anxiety disorders
• Panic disorder
• Initial treatment of mania or acute psychosis together with firstline drugs such as lithium  haloperidol or risperidone
• Hyperekplexia  - (literally meaning "exaggerated surprise") is a neurologic disorder classically characterised by pronounced startle responses to tactile or acoustic stimuli.  Many forms of parasomnia - restless legs syndrome, bruxism, rapid eye movement behavior disorder
• The treatment of acute and chronic akathisia induced by antipsychotics - Akathisia,  is a syndrome characterized by unpleasant sensations of inner restlessness that manifests itself with an inability to sit still or remain motionless
• Spasticity related to amyotrophic lateral sclerosis
• Obsessive compulsive disorder
• Clinical depression

 One somewhat bizarre recommended use of this drug is in the “management of the visual effects of HPPD”.   Hallucinogen persisting perception disorder (HPPD) is a disorder characterized by a continual presence of visual disturbances that are reminiscent of those generated by the ingestion of hallucinogenic substances!  “Previous use of hallucinogens by the person is needed, though not sufficient, for diagnosing someone with the disorder”. For an individual to be diagnosed with HPPD, the symptoms cannot be due to another medical condition.  In effect the company selling this product recommends the use of the drug, which can induce hallucinations and is addictive,  to a vulnerable group of people with hallucinations!

The side effects – are similar to all the benzodiazepines. 

Use of alcohol or other CNS depressants while taking clonazepam greatly intensifies the effects (and side-effects) of the drug.  A 2006 US government study of nationwide emergency department (ED) visits found that Clonazepam was the second most frequently implicated benzodiazepine in Emergency department visits .

Withdrawal symptoms - As with all benzodiazepines.