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Observations placeholder

Olanzapine and Zyprexa

Identifier

001500

Type of Spiritual Experience

Hallucination

Number of hallucinations: 902

Background

A description of the experience

Olanzapine –     Trade names Zyprexa  , Zyprexa Zydis , Zalasta, Zolafren, Olzapin, Oferta, Zypadhera or in combination with fluoxetene as Symbax.  As you can see the number of hallucinations caused by this drug is extremely high.  Olanzapine is an atypical antipsychotic structurally similar to Clozapine, but is classified as a thienobenzodiazepine. Sales of Zyprexa in 2008 were $2.2B in the US alone, and $4.7B in total. 

It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder.

It is a hugely complex drug, meaning that, like Clozapine, the effects will be largely unpredictable .  The literature states “The mode of action of olanzapine's antipsychotic activity is unknown”.  Olanzapine has a higher affinity for 5-HT2 serotonin receptors than D2 dopamine receptors. Other affinities are:

  • dopamine D1: 31
  • dopamine D2: 11
  • serotonin 5-HT2A: 4
  • serotonin 5-HT2C: 11
  • muscarinic M1: 1.9
  • adrenergic alpha1: 19

and  also exhibits weak affinity for GABAA, BZD receptor site.  It is clear, however, that amongst the list of side effects are some very well known antimuscarinic ones [I have not listed all the side effects, the list was too long]:

  • dry mouth
  • dizziness
  • sedation
  • constipation
  • urinary retention
  • impaired judgment, thinking, and motor skills
  • impaired spatial orientation
  • impaired responses to senses
  • seizures
  • trouble swallowing
  • problems with keeping body temperature regulated
  • Auditory Hallucinations

On Aug, 8, 2015: 11,964 people reported to have side effects when taking Olanzapine. Among them, 150 people (1.25%) have Hallucination.

Time on Olanzapine when people have Hallucination  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Hallucination 55.56% 22.22% 7.41% 7.41% 3.70% 3.70% 0.00%

Gender of people who have Hallucination when taking Olanzapine  :

  Female Male
Hallucination 38.38% 61.62%

Age of people who have Hallucination when taking Olanzapine  :

  0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Hallucination 0.00% 0.00% 8.43% 21.08% 6.02% 19.88% 10.24% 34.34%

Severity of Hallucination when taking Olanzapine  :

  least moderate severe most severe
Hallucination 0.00% 0.00% 0.00% 100.00%

 

On Jul, 25, 2015: 42,794 people reported to have side effects when taking Zyprexa. Among them, 739 people (1.73%) have Hallucination.

Time on Zyprexa when people have Hallucination  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Hallucination 39.39% 18.18% 9.70% 3.64% 24.85% 4.24% 0.00%

Gender of people who have Hallucination when taking Zyprexa  :

  Female Male
Hallucination 57.11% 42.89%

Age of people who have Hallucination when taking Zyprexa  :

  0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Hallucination 0.00% 1.65% 7.10% 13.31% 16.73% 16.86% 17.11% 27.25%

Severity of Hallucination when taking Zyprexa  :

  least moderate severe most severe
Hallucination 0.00% 50.00% 50.00% 0.00%

 

On Jul, 29, 2015: 597 people reported to have side effects when taking Zyprexa zydis. Among them, 13 people (2.18%) have Hallucination.

Time on Zyprexa zydis when people have Hallucination  :

  < 1 month 1 - 6 months 6 - 12 months 1 - 2 years 2 - 5 years 5 - 10 years 10+ years
Hallucination 68.00% 20.00% 8.00% 0.00% 0.00% 4.00% 0.00%

Gender of people who have Hallucination when taking Zyprexa zydis  :

  Female Male
Hallucination 13.89% 86.11%

The source of the experience

eHealthme

Concepts, symbols and science items

Concepts

Symbols

Science Items

Activities and commonsteps

Commonsteps

References

On EROWID, those who were ill call it a life saver. The mildest comment from someone who was not ill was that it had ‘no recreational value’. 

 http://www.erowid.org/experiences/subs/exp_Pharms_Olanzapine.shtml

EROWID has some interesting case histories of effects too 

http://www.erowid.org/pharms/olanzapine/olanzapine.shtml