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Toxicity of titanium dioxide nanoparticles in central nervous system
Identifier
022804
Type of Spiritual Experience
Background
A description of the experience
Toxicol In Vitro. 2015 Aug;29(5):1042-52. doi: 10.1016/j.tiv.2015.04.004. Epub 2015 Apr 18.
Toxicity of titanium dioxide nanoparticles in central nervous system.
Czajka M1, Sawicki K2, Sikorska K3, Popek S2, Kruszewski M4, Kapka-Skrzypczak L5.
- 1Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland. Electronic address: czajka.magdalenaa@gmail.com.
- 2Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland.
- 3Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Warsaw, Poland.
- 4Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland; Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Warsaw, Poland; Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszów, Poland.
- 5Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland; Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszów, Poland.
Abstract
Titanium dioxide nanoparticles (TiO2 NPs) have found many practical applications in industry and daily life.
A widespread application of TiO2 NPs rises the question about safety of their use in the context of potential occupational, environmental and intentional exposure of humans and biota.
TiO2 NPs easily enter the body through inhalation, cross blood-brain barrier and accumulate in the brain, especially in the cortex and hippocampus.
Toxicity of these NPs and the molecular mechanisms of their action have been studied extensively in recent years. Studies showed that TiO2 NPs exposure resulted in microglia activation, reactive oxygen species production, activation of signaling pathways involved in inflammation and cell death, both in vitro and in vivo.
Consequently, such action led to neuroinflammation, further brain injury. A spatial recognition memory and locomotor activity impairment has been also observed.
Copyright © 2015 Elsevier Ltd. All rights reserved.
KEYWORDS:
Apoptosis; Brain; Neuroinflammation; Reactive oxygen species; Toxicity
PMID: 25900359