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Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades.

Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium.

• Central nervous system: drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold.
• Peripheral side effects: blurred vision, dry mouth, impaired sweating, abdominal discomfort, and constipation are frequent. Tachycardia may be noted. Allergic skin reactions may occur. Parenteral use may cause orthostatic hypotension.
• Eyes: trihexyphenidyl causes mydriasis with or without photophobia. It may precipitate narrow angle glaucoma.
• Tolerance may develop during therapy which requires dose adjustments.

On Feb, 1, 2016: 351 people reported to have side effects when taking Trihexyphenidyl hydrochloride. Among them, 20 people (5.70%) have Hallucination.

On Feb, 4, 2016: 351 people reported to have side effects when taking Trihexyphenidyl hydrochloride. Among them, 8 people (2.28%) have Death.

Time on Trihexyphenidyl hydrochloride when people have Death  :