Observations placeholder
Retrovir
Identifier
020002
Type of Spiritual Experience
Background
A description of the experience
Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS
Side effects
Early long-term higher-dose therapy with AZT was initially associated with side effects that sometimes limited therapy, including anemia, neutropenia, hepatotoxicity, cardiomyopathy, and myopathy. All of these conditions were generally found to be reversible upon reduction of AZT dosages. They have been attributed to several possible causes, including transient depletion of mitochondrial DNA, sensitivity of the γ-DNA polymerase in some cell mitochondria] the depletion of thymidine triphosphate, oxidative stress, reduction of intracellular L-carnitine or apoptosis of the muscle cells. Anemia due to AZT was successfully treated using vitamins to stimulate red blood cell production. Drugs that inhibit hepatic glucuronidation, such as indomethacin, nordazepam, acetylsalicylic acid (aspirin) and trimethoprim, decreased the elimination rate and increased the therapeutic strength of the medication] Most common side-effects included upset stomach and acid reflux (heartburn), headache, cosmetic reduction in abdominal body fat, light sleeping, and occasional loss of appetite; while less-common complaints included faint discoloration of fingernails and toenails, mood elevation, occasional tingling or transient numbness of the hands or feet, and minor skin discoloration. Allergic reactions were rare Today, side-effects are much less common with the use of lower doses of AZT According to IARC, there is sufficient evidence in experimental animals for the carcinogenicity of zidovudine; it is possibly carcinogenic to humans (Group 2B)
On Feb, 7, 2016: 6,585 people reported to have side effects when taking Retrovir. Among them, 8 people (0.12%) have Hallucination.
Time on Retrovir when people have Hallucination :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Hallucination | 0.00% | 100.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Age of people who have Hallucination when taking Retrovir :
| 0-1 | 2-9 | 10-19 | 20-29 | 30-39 | 40-49 | 50-59 | 60+ | |
| Hallucination | 25.00% | 0.00% | 12.50% | 0.00% | 12.50% | 0.00% | 37.50% | 12.50% |
On Feb, 7, 2016: 6,585 people reported to have side effects when taking Retrovir. Among them, 46 people (0.70%) have Death.
Time on Retrovir when people have Death :
| < 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
| Death | 41.67% | 19.44% | 8.33% | 11.11% | 5.56% | 13.89% | 0.00% |
Age of people who have Death when taking Retrovir :
| 0-1 | 2-9 | 10-19 | 20-29 | 30-39 | 40-49 | 50-59 | 60+ | |
| Death | 36.36% | 4.55% | 0.00% | 2.27% | 31.82% | 22.73% | 2.27% | 0.00% |
Top conditions involved for these people :
- Hiv infection (34 people, 73.91%)
- Acquired immunodeficiency syndrome (3 people, 6.52%)
- Hepatitis c (2 people, 4.35%)