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Orphenadrine (sold under the brand names Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan, Norgesic, OrfenAce, and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions, as well as the treatment of some aspects of Parkinson's disease.

It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's, such as benztropine and trihexyphenidyl, and it is also structurally related to nefopam which is a centrally acting yet nonopioid analgesic. Despite the fact it is an anticholinergic it appears to be being used off label for pain "The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches."

Orphenadrine has about 58% of the anticholinergic potency of atropine at equivalent doses.

On Jan, 17, 2016: 515 people reported to have side effects when taking Orphenadrine citrate. Among them, 19 people (3.69%) have Hallucination.

Time on Orphenadrine citrate when people have Hallucination  :

On Jan, 14, 2016: 515 people reported to have side effects when taking Orphenadrine citrate. Among them, 4 people (0.78%) have Death.