Observations placeholder
Histidine deficiency, filaggrin and psoriasis
Identifier
019127
Type of Spiritual Experience
Background
The epidermis protects human subjects from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis.
Filaggrin is a crucial epidermal protein that is important for the formation of the corneocyte, as well as the generation of its intracellular metabolites, which contribute to stratum corneum hydration and pH.
And filaggrin is made from Histidine.
Filaggrin deficiency is lso observed in patients with atopic dermatitis regardless of filaggrin mutation status, suggesting that the absence of filaggrin is a key factor in the pathogenesis of this skin condition too not just psoriasis.
Anthracene is derived from coal tar. The 'treatment' is not relevant to the findings.
A description of the experience
G Ital Dermatol Venereol. 1989 Apr;124(4):141-5.
[Study of filaggrin in psoriasis].
[Article in Italian]
Fedi AM, Leoncini P, Farella V, Lotti T.
Abstract
Filaggrin is a histidine-rich basic protein that aggregates keratin filaments in fully differentiated cells of the epidermis.
Filaggrin is synthesized in the granular cell layer as a high-Mr phosphorylated precursor, profilaggrin, that is processed to form the lower-Mr product present in cornified cells. The catabolism of filaggrin in stratum corneum produces urocanic acid and carboxylic-pyrrolidone acid that, respectively, absorb UV radiations and support cutaneous hydratation.
In this study we evaluated by direct-immunofluorescence and by immunoperoxidase staining using rabbit antihuman filaggrin antiserum localization of filaggrin in psoriatic skin and in normal human skin before and after treatment with anthralin 0.1%, betamethasone 0.05% and hydrocolloid dressing.
Antiserum against human filaggrin reacted with tissue sections of normal human skin, staining cells in the granular layer and in the stratum corneum, while no staining of human psoriatic skin sections was observed.
After treatments, filaggrin resulted present in those psoriatic skin sections that showed complete clinical remission, while it was not observed in psoriatic patches which did not clear. These studies suggest that human skin filaggrin can be considered a marker of clinical remission of psoriasis.
PMID: 2680915