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Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to freeze tissue in a specific area. It is used by injecting it into the area, around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to make it last longer. It typically begins working within 15 minutes and lasts for 2 to 8 hours.

Possible side effects include sleepiness, muscle twitching, ringing in the ears, changes in vision, low blood pressure, and an irregular heart rate. There are concerns that injecting it into a joint can cause problems with the cartilage. Concentrated bupivacaine is not recommended for epidural freezing. Epidural freezing may also increase the length of labor. It is a local anaesthetic of the amide group.

Bupivacaine was discovered in 1957. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. Bupivacaine is available as a generic medication and is not very expensive.

On Sep, 18, 2015: 3,500 people reported to have side effects when taking Bupivacaine. Among them, 18 people (0.51%) have Hallucination.

On Sep, 18, 2015: 1,896 people reported to have side effects when taking Marcaine. Among them, 10 people (0.53%) have Hallucination.