J Matern Fetal Neonatal Med. 2010 Aug;23(8):932-4. doi: 10.3109/14767050903317708.

A safe strategy to decrease fetal lead exposure in a woman with chronic intoxication.

Leiba A1, Hu H, Zheng A, Kales SN.

• 1Department of Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA. drleiba@gmail.com

During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development.

The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established.

We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We

• (a) advised her to delay conception until 'toxicological clearance',
• (b) treated her with multiple courses of lead chelator, DMSA, and
• (c) prescribed oral calcium.

Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure.

PMID: 20459344