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Baclofen  - Baclofen (brand names Kemstro, Lioresal , and Gablofen) is primarily used to treat spasticity.  It is widely used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, spastic diplegia cerebral palsy, multiple sclerosis, amyotrophic lateral sclerosis (Lou Gehrig's disease), peripheral neuropathy and trigeminal and glossopharyngeal neuralgias.  Baclofen is often the primary, or at least preliminary, drug treatment for spastic diplegia and more general spasticity-based mobility impairments. Research has not, however, shown it to be consistently effective in improving function for people with these issues. Sometimes, effects are immediate and clear; other times, effects may be mild, vague, or nonexistent.

It is an agonist for the GABAB receptors.  Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. One property of baclofen is that tolerance does not seem to occur to any significant degree — baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. However, oral dosage must be carefully regulated; significantly high doses of the drug, particularly 80 milligrams per day or higher, can cause excessive drowsiness that can interfere with daily function