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Allergic reaction to Potassium dichromate - Pharmaceutical companies

Identifier

014507

Type of spiritual experience

Background

Potassium dichromate is one of the most common causes of chromium dermatitis; chromium is highly likely to induce sensitization leading to dermatitis, especially of the hand and fore-arms, which is chronic and difficult to treat. Toxicological studies have further illustrated its highly toxic nature. With rabbits and rodents, concentrations as low as 14 mg/kg have shown a 50% fatality rate amongst test groups. Aquatic organisms are especially vulnerable if exposed.

As with other CrVI compounds, potassium dichromate is carcinogenic. The compound is also corrosive and exposure may produce severe eye damage or blindness. Human exposure further encompasses impaired fertility, heritable genetic damage and harm to unborn children.

A description of the experience

Contact Dermatitis. 2015 Jan 19. doi: 10.1111/cod.12346. [Epub ahead of print]

Contact allergy trends in Sweden - a retrospective comparison of patch test data from 1992, 2000, and 2009.

Fall S1, Bruze M, Isaksson M, Lidén C, Matura M, Stenberg B, Lindberg M.

BACKGROUND:

Contact allergy prevalence rates change over time as a result of variations in allergen exposure. Data from patch test clinics are often used as markers for allergy trends.

OBJECTIVES:

The aim of the present retrospective study was to describe trends in rates of sensitization to allergens in the Swedish baseline series.

PATIENTS/MATERIALS/METHODS:

Prevalence rates are described by comparing consecutive patch test data from 1992, 2000 and 2009 in Swedish patch test clinics. In total, 3680 patients were included in 1992, 3825 in 2000, and 3112 in 2009.

RESULTS:

Among test substances with a sensitization rate above 2% in 2009, significant decreases were noted for nickel sulfate, cobalt chloride, colophonium, and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), and a significant increase for p-phenylenediamine, as compared with 1992.

Potassium dichromate reactions had increased among younger women, whereas reactions to nickel and cobalt had decreased in this group. Sensitization to chromium, cobalt and fragrance mix I had decreased among older men, and sensitization to nickel had decreased among younger men.

CONCLUSIONS:

It is probable that these changes in 1992-2009 reflect both changes in regulations for nickel, lower levels of chromium in cement and of MCI/MI in cosmetics, and increasing use of hair dyes.

© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

KEYWORDS:

contact allergy; contact dermatitis; epidemiology; patch testing; prevalence; trends

PMID:

25600880

The source of the experience

PubMed

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Activities